Genetic Variants of Vitiligo
نویسندگان
چکیده
منابع مشابه
Association of CYP2C9 Genetic Variants with Vitiligo
BACKGROUND Vitiligo is a depigmenting skin disorder in which genetic factors play an important role. OBJECTIVE To examine the association of CYP2C9 (*) 1/(*) 2/(*) 3 gene polymorphism with vitiligo. METHODS In this case controlled study, 95 Saudi patients with vitiligo (50 men and 45 women), with a mean age of 27.3 years, were analyzed. Patients were compared to 86 healthy controls from the...
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Psoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotype...
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Genetic polymorphisms in TNFB are involved in the regulation of its expression and are found to be associated with various autoimmune diseases. The aim of the present study was to determine whether TNFB +252A/G (rs909253) and exon 3 C/A (rs1041981) polymorphisms are associated with vitiligo susceptibility, and expression of TNFB and ICAM1 affects the disease onset and progression. We have earli...
متن کاملGenetic Epidemiology and Heritability of Vitiligo
1.1 Prevalence & incidence The population prevalence of vitiligo ranges from 0.1% to 2% and shows a wide variability among ethnic groups (Bolognia et al., 1998; Hann and Nordlund, 2000). Whereas the estimated population prevalence of vitiligo is approximately 0.38% for Caucasians in the United States and Northern Europe (Howitz et al., 1977), vitiligo affects 0.19% of the population in China (X...
متن کاملAssociation of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility
BACKGROUND Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. NPY plays an important role in induction of immune response by acting on a variety of immune cells. NPY synthesis and release is governed by IL1B. Moreover, genetic variability in IL1B is reported to be associated with elevated NPY levels. OBJECTIVES Aim of the present study was to explor...
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ژورنال
عنوان ژورنال: Clinical Dermatology Open Access Journal
سال: 2018
ISSN: 2574-7800
DOI: 10.23880/cdoaj-16000162